High prevalence for obesity in severe COVID-19: Possible links and perspectives towards patient stratification.
Identifieur interne : 000E36 ( Main/Exploration ); précédent : 000E35; suivant : 000E37High prevalence for obesity in severe COVID-19: Possible links and perspectives towards patient stratification.
Auteurs : Isabelle Dugail [France] ; Ez-Zoubir Amri [France] ; Nicolas Vitale [France]Source :
- Biochimie [ 1638-6183 ] ; 2020.
Abstract
It is becoming obvious that in addition to aging and various hearth pathologies, excess of body weight, especially obesity is a major risk factor for severity of COVID-19 infection. Intriguingly the receptor for SARS-CoV-2 is ACE2, a member of the angiotensin receptor family that has a relatively large tissue distribution. This observation likely explains the multitude of symptoms that have been described from human patients. The adipose tissue also expresses ACE2, suggesting that adipocytes are potentially infected by SARS-CoV-2. Here we discuss some of the potential contribution of the adipose tissue to the severity of the infection and propose some aspects of obese patients metabolic phenotyping to help stratification of individuals with high risk of severe disease.
DOI: 10.1016/j.biochi.2020.07.001
PubMed: 32649962
PubMed Central: PMC7340594
Affiliations:
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Intriguingly the receptor for SARS-CoV-2 is ACE2, a member of the angiotensin receptor family that has a relatively large tissue distribution. This observation likely explains the multitude of symptoms that have been described from human patients. The adipose tissue also expresses ACE2, suggesting that adipocytes are potentially infected by SARS-CoV-2. Here we discuss some of the potential contribution of the adipose tissue to the severity of the infection and propose some aspects of obese patients metabolic phenotyping to help stratification of individuals with high risk of severe disease.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">32649962</PMID><DateRevised><Year>2020</Year><Month>09</Month><Day>09</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1638-6183</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2020</Year><Month>Jul</Month><Day>08</Day></PubDate></JournalIssue><Title>Biochimie</Title><ISOAbbreviation>Biochimie</ISOAbbreviation></Journal><ArticleTitle>High prevalence for obesity in severe COVID-19: Possible links and perspectives towards patient stratification.</ArticleTitle><ELocationID EIdType="pii" ValidYN="Y">S0300-9084(20)30155-3</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.biochi.2020.07.001</ELocationID><Abstract><AbstractText>It is becoming obvious that in addition to aging and various hearth pathologies, excess of body weight, especially obesity is a major risk factor for severity of COVID-19 infection. Intriguingly the receptor for SARS-CoV-2 is ACE2, a member of the angiotensin receptor family that has a relatively large tissue distribution. This observation likely explains the multitude of symptoms that have been described from human patients. The adipose tissue also expresses ACE2, suggesting that adipocytes are potentially infected by SARS-CoV-2. Here we discuss some of the potential contribution of the adipose tissue to the severity of the infection and propose some aspects of obese patients metabolic phenotyping to help stratification of individuals with high risk of severe disease.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier B.V. and Société Française de Biochimie et Biologie Moléculaire (SFBBM). All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Dugail</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>UMRS 1269 INSERM/Sorbonne University, Nutriomics, Faculté de médecine Pitié-Salpêtrière, F-75013, Paris, France; Member of the scientific council of the Groupe d'Etude et de Recherche en Lipidomique (GERLI), France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Amri</LastName><ForeName>Ez-Zoubir</ForeName><Initials>EZ</Initials><AffiliationInfo><Affiliation>Université Côte d'Azur, CNRS, Inserm, iBV, Nice, France; Member of the scientific council of the Groupe d'Etude et de Recherche en Lipidomique (GERLI), France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vitale</LastName><ForeName>Nicolas</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Centre National de la Recherche Scientifique, Université de Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, F-67000, Strasbourg, France; Member of the scientific council of the Groupe d'Etude et de Recherche en Lipidomique (GERLI), France. 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|clé= pubmed:32649962
|texte= High prevalence for obesity in severe COVID-19: Possible links and perspectives towards patient stratification.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:32649962" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidFranceV1
| This area was generated with Dilib version V0.6.37. |  |